Astragaloside I, one of the main active ingredients in Astragalus membranaceus, has osteogenic properties. Astragaloside I stimulates osteoblast differentiation through the Wnt/β-catenin signaling pathway.
体外研究
Astragaloside I (10-40 μM) upregulates the express of β-catenin, Runx2, BGP and OPG, RANKL (osteogenesis marker genes) in MC3T3-E1 cells.
Western Blot Analysis.
Cell Line:
MC3T3-E1 cells.
Concentration:
0, 10, 20, 40 μM.
Incubation Time:
5 days.
Result:
Stimulated the expression of β-catenin and Runx2.
Cell Cytotoxicity Assay.
Cell Line:
MC3T3-E1 cells.
Concentration:
0, 10, 20, 40 μM.
Incubation Time:
1, 3 or 6 days (The media was changed every 2 days).
Result:
No obvious cytotoxic effect was observed in the MC3T3-E1 cells.
分子式
C43H68O16
分子量
869.04
CAS号
84680-75-1
运输条件
Room temperature in continental US; may vary elsewhere.