Suramin sodium salt - CAS:129-46-4

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Suramin sodium salt (Synonyms:苏拉明钠; Suramin hexasodium salt)

目录号 : KM15203 CAS No. : 129-46-4 纯度 : ≥98%

Data Sheet 产品使用指南

Suramin sodium salt (Suramin hexasodium salt) 是一种可逆的竞争性蛋白酪氨酸磷酸酶 (PTPases) 抑制剂。Suramin sodium salt 是有效的 sirtuins 抑制剂：SirT1 (IC₅₀=297 nM)，SirT2 (IC₅₀=1.15 μM)，SirT5 (IC₅₀=22 μM)。Suramin sodium salt 是竞争性逆转录酶抑制剂 (DNA topoisomerase II: IC₅₀=5 μM)。Suramin sodium salt 是一种有效的 SARS-CoV-2 RNA 依赖性 RNA 聚合酶 (RdRp) 抑制剂。Suramin sodium salt 有效抑制 IP5K，并且是抗寄生虫 (antiparasitic)，抗肿瘤和抗血管生成剂。

规格	价格	是否有货
25mg		In-stock
50mg		In-stock
100mg	询价	In-stock

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生物活性

Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor. Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC₅₀=297 nM), SirT2 (IC₅₀=1.15 μM), and SirT5 (IC₅₀=22 μM). Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC₅₀=5 μM). Suramin sodium salt is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor. Suramin sodium salt efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent.

体外研究

Suramin sodium salt (Suramin hexasodium salt; 50-600 μg/mL; for 24-96 hours) inhibits cells proliferation in a dose-dependent and time-dependent manner and decreases viability in cancer cells.
Suramin sodium salt (300 μg/mL; for 48 hours) induces cells apoptosis and down-regulates mRNA expression in HeLa cells.
Suramin sodium salt (1 mg/mL; 1 hour) significantly suppresses the phosphorylated ERK1/2.
The IC₅₀ values of HO-8910 PM and HeLa are 319 μg/mL, 476 μg/mL, respectively.
Suramin blocks viral replication in Vero E6 cells.

Cell Proliferation Assay

Cell Line:	HO-8910 PM ovarian and Hela cervical cancer cells
Concentration:	50, 100, 200, 300, 400, 500 and 600 μg/mL
Incubation Time:	For 24, 48, 72 and 96 hours
Result:	Inhibited cells proliferation in a dose-dependent and time-dependent manner.

Apoptosis Analysis

Cell Line:	HeLa cells
Concentration:	300 μg/mL
Incubation Time:	For 48 hours
Result:	Induced cells apoptosis.

Western Blot Analysis

Cell Line:	PA-SMCs cells
Concentration:	1 mg/mL
Incubation Time:	For 1 hour
Result:	Significantly suppressed the phosphorylated ERK1/2.

体内研究

Suramin sodium salt (Suramin hexasodium salt; 10 mg/kg; IV; twice weekly for 3 weeks) reverses established pulmonary hypertension (PH), thereby normalizing the pulmonary artery pressure values and vessel structure.

Animal Model:	Adult male Wistar rats (200-225 g)
Dosage:	10 mg/kg
Administration:	IV; twice weekly for 3 weeks
Result:	Reversed established PH, thereby normalizing the pulmonary artery pressure values and vessel structure.

分子式

C₅₁H₃₄N₆Na₆O₂₃S₆

分子量

1429.17

CAS号

129-46-4

中文名称

苏拉明钠

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

H₂O : ≥ 200 mg/mL (139.94 mM)

DMSO : 125 mg/mL (87.46 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.6997 mL	3.4985 mL	6.9971 mL
5 mM	0.1399 mL	0.6997 mL	1.3994 mL
10 mM	0.0700 mL	0.3499 mL	0.6997 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (69.97 mM); Clear solution; Need ultrasonic
2.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.08 mg/mL (1.46 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (1.46 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
3.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (1.46 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (1.46 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

临床试验

科研文献

纯度： ≥98%

Data Sheet

产品使用指南

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

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分子量*

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

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KKL 顾客使用本产品发表的 8 篇科研文献

The molarity calculator equation

The dilution calculator equation