Leupeptin hemisulfate - CAS:103476-89-7

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Leupeptin hemisulfate (Synonyms:亮肽素)

目录号 : KM15086 CAS No. : 103476-89-7 纯度 : 97%

Data Sheet 产品使用指南

Leupeptin hemisulfate 是一种可透过膜的巯基蛋白酶抑制剂，可抑制 Cathepsin B, Cathepsin H 和 Cathepsin L，并损害两性溶酶体的融合。Leupeptin hemisulfate 也具有抗炎作用。

规格	价格	是否有货
5mg		In-stock
10mg		In-stock
50mg		In-stock
100mg	询价	In-stock
200mg	询价	In-stock

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生物活性

Leupeptin hemisulfate is a membrane-permeable thiol protease inhibitor that inhibits Cathepsin B, Cathepsin H and Cathepsin L, and also impairs amphisome-lysosome fusion. Leupeptin hemisulfate also exhibits anti-inflammatory effect.

体内研究

Leupeptin (0-36 mg/kg; intraperitoneal injection; for 4 hours; C57BL/6NCrl male mice) is well tolerated by the animals and produces a strong, dose-dependent increase in LC3b-II in both the total tissue extracts and the lysosome and autophagosome-enriched pellet fraction.

Animal Model:	C57BL/6NCrl male mice (6-8 weeks old, 20-25 g)
Dosage:	0 mg/kg, 9 mg/kg, 18 mg/kg, 36 mg/kg
Administration:	Intraperitoneal injection; for 4 hours
Result:	Promoted the accumulation of LC3b-II in mouse liver.

分子式

C₄₀H₇₈N₁₂O₁₂S

分子量

475.59

CAS号

103476-89-7

中文名称

亮肽素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-80°C	2 years
	-20°C	1 year
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : ≥ 19 mg/mL (39.95 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1027 mL	10.5133 mL	21.0265 mL
5 mM	0.4205 mL	2.1027 mL	4.2053 mL
10 mM	0.2103 mL	1.0513 mL	2.1027 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

科研文献

纯度： 97%

Data Sheet

产品使用指南

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

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Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 9 篇科研文献

The molarity calculator equation

The dilution calculator equation