Acetamiprid is a neonicotinoid insecticide used worldwide. Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist, and is shown to be associated with neuromuscular and reproductive disorders.
IC50&Target
nAChR
体内研究
Acetamiprid decreases in body weight and mildly affected spermatogenesis. .
Acetamiprid decreases the expression of testosterone-metabolism genes, nAChR subunit genes, and proliferation-associated genes in mice.
Acetamiprid disrupts subsequent testosterone biosynthesis by decreasing the rate of conversion of cholesterol to testosterone and by preventing cholesterol from entering the mitochondria within the Leydig cells. These effects caused reproductive damage to the rats.
Animal Model:
Male Sprague Dawley (SD) rats
Dosage:
10 mg/kg, 30 mg/kg
Administration:
Oral gavage; daily; for 35 days
Result:
Inhibited testosterone synthesis by affecting the mitochondrial function and cytoplasmic adenosine triphosphate production in rat Leydig cells.
分子式
C10H11ClN4
分子量
222.67
CAS号
135410-20-7
中文名称
啶虫脒
运输条件
Room temperature in continental US; may vary elsewhere.