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CRF, bovine (TFA) is a potent agonist of CRF receptor, and displaces [I-Tyr]ovine CRF with a K_i of 3.52 nM.

CRF, bovine is a potent agonist of CRF receptor, and displaces [I-Tyr]ovine CRF with a K_i of 3.52 nM. CRF shows pEC₅₀s of 11.16, 8.53 and 8.70 for human CRF₁, human CRF₂ and rat CRF_2α. CRF is released from hypothalamic-pituitary-adrenal (HPA) axis induced by stress, and leads to production of glucocorticoids which down regulate immune responses. CRF also has proinflammatory effects. CRF affects brain microvessel endothelial cells (BMEC) structure or function, CRF (100 nM) significantly increases cAMP in BMEC.

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