Ammonium chloride, as a heteropolar compound with pH value regulation, can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system. Ammonium chloride is an autophagy inhibitor.
体外研究
Ammonium chloride (NH4Cl), a lysosomotropic agent that raises intralysosomal pH, reduces the yield of reovirus during infection of mouse L cells.
体内研究
Ammonium chloride (0.28 M in drinking water) promotes the survival of myocardial cells in vivo by decreasing contractile dysfunction, cardiac hypertrophy, inflammation, apoptosis and autophagy.
Animal Model:
8-9-week-old C57B/L6 mice
Dosage:
0.28 M in drinking water (5 mg/kg doxorubicin once a week for 2 weeks)
Administration:
0.28 M in drinking water (5 mg/kg doxorubicin once a week for 2 weeks)
Result:
Effectively improved doxorubicin (DOX)-induced cardiomyocyte apoptosis and cardiac dysfunction in mice.
分子式
ClH4N
分子量
53.49
CAS号
12125-02-9
运输条件
Room temperature in continental US; may vary elsewhere.