Azure B 是一种阳离子染料 (cationic dye)，是 Methylene blue 的主要代谢物，用于 Azure 曙红染色剂以进行血液涂片染色。Azure B 是一种高效、选择性和可逆的抑制单胺氧化酶 (MAO)-A 的抑制剂，对重组人的 MAO-A 和 MAO-B 的IC50 分别为 11 和 968 nM。Azure B 具有显著的抗抑郁作用。
| 生物活性 |
Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC50s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects. |
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| 体内研究 |
Azure B (4-30 mg/kg; i.p.; once) decreases immobility in the forced swim test (FST).
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| 分子式 |
C15H16ClN3S
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| 分子量 |
305.83
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| CAS号 |
531-55-5
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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纯度： 96%
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