Gitogenin - CAS:511-96-6

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Gitogenin

目录号 : KM14820 CAS No. : 511-96-6 纯度 : 98%

Data Sheet 产品使用指南

Gitogenin 是从 Tribulus longipetalus 整株中分离出来的一种天然类固醇，是 UDP-葡萄糖醛酸转移酶 1A4 (UGT1A4) 和 α-葡萄糖苷酶的选择性抑制剂，其 IC₅₀ 值分别为 0.69 µM (使用三氟拉嗪为底物) 和 37.2 μM，并且不抑制人类主要细胞色素 P450 亚型的活性。

规格	价格	是否有货
5mg		In-stock
10mg		In-stock
20mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

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生物活性

Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme α-glucosidase with IC₅₀ values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major human cytochrome P450 isoforms.

体外研究

When tamoxifen is used as the substrate metabolized by UGT1A4 in HLMs, Gitogenin exhibits potent inhibition of tamoxifen, with an IC₅₀ value of 6.13 µM. Similarly, for midazolam as the substrate of UGT1A4, the IC₅₀ value is 5.7 µM. In addition, when olanzapine is used as a substrate of UGT1A4, the IC₅₀ value is determined as 6.0 µM. Finally, we also evaluats Gitogenin for asenapine glucuronidation mediated by UGT1A4, and similar inhibition effect is observed, with an IC₅₀ value of 22.0 µM.

体内研究

Stimulation of growth hormone release is investigated on rat pituitary cells in vitro. Gitogenin (20 μg/mL) shows rat growth-hormone (rGH) release stimulating activities (26.1 ng/mL).

分子式

C₂₇H₄₄O₄

分子量

432.64

CAS号

511-96-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 1.85 mg/mL (4.28 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3114 mL	11.5570 mL	23.1139 mL
5 mM	---	---	---
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

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