Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively.
体外研究
Atorvastatin treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction, and the endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation.
体内研究
Atorvastatin (20-30 mg/kg; oral gavage; once a day; for 28 days; ApoE mice) treatment significantly reduces endoplasmic reticulum (ER) stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE-/- mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β are all remarkably inhibited after Atorvastatin treatment.
Animal Model:
Forty 8-week-old ApoE mice induced with angiotensin II (Ang II)
Dosage:
20 mg/kg, 30 mg/kg
Administration:
Oral gavage; once a day; for 28 days
Result:
Significantly reduced ER stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β were all remarkably inhibited
分子式
C33H35FN2O5
分子量
558.64
CAS号
134523-00-5
中文名称
阿托伐他汀;阿托他伐汀
运输条件
Room temperature in continental US; may vary elsewhere.