Moxifloxacin Hydrochloride (Synonyms:莫西沙星盐酸盐; BAY 12-8039)
目录号 : KM14525 CAS No. : 186826-86-8 纯度 : 98%

Moxifloxacin Hydrochloride (BAY 12-8039) 是一种口服有效的 8-甲氧基喹诺酮类抗菌药物,用于急性细菌性鼻窦炎,慢性支气管炎的急性细菌性加重和感染性肺炎的研究。

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5g 询价 In-stock

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生物活性

Moxifloxacin Hydrochloride (BAY 12-8039) is an oral 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia.

体外研究

The in vitro activities of Moxifloxacin Hydrochloride (BAY 12-8039) and Amoxicillin are compared by time-kill curve and inhibition of intracellular growth experiments by using a model of bone marrow-derived mouse macrophages infected by L. monocytogenes EGDe. Moxifloxacin acts much more rapidly, beginning to exert its effects in the first 3 h and achieving complete broth sterilization within 24 h of incubation. Moxifloxacin appears to have a protective effect against macrophage lysis, as many cells are still viable after 24 h of incubation.

体内研究

Moxifloxacin (BAY 12-8039; 12 mg/kg; intravenous injection; once-three times per day; for 7 days; white male Wistar rats) treatment every 8 hours is accompanied by longer survival. Tissue cultures 30 hours after bacterial challenge shows considerably less bacterial overgrowth in the spleens and lungs of moxifloxacin-treated than in salinetreated animals and without being toxic.

Animal Model: 144 white male Wistar rats (18-22 weeks; 300-400 g) infected Stenotrophomonas maltophilia
Dosage: 12 mg/kg
Administration: Intravenous injection; once per day, twice per day, three times per day; for 7 days
Result: Showed considerably less bacterial overgrowth in the spleens and lungs and without being toxic.
分子式
C21H25ClFN3O4
分子量
437.89
CAS号
186826-86-8
中文名称
盐酸莫西沙星;莫西沙星盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : ≥ 31 mg/mL (70.79 mM)

H2O : 16.67 mg/mL (38.07 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2837 mL 11.4184 mL 22.8368 mL
5 mM 0.4567 mL 2.2837 mL 4.5674 mL
10 mM 0.2284 mL 1.1418 mL 2.2837 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

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科研文献
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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