Lactoferrin 17-41 (Lactoferricin B) acetate, a peptide corresponding to residues 17-41 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms, including Gram-positive and Gramnegative bacteria, viruses, protozoa, and fungi. Lactoferrin 17-41 acetate has antitumor activities.
体外研究
Lactoferrin 17-41 (Lactoferricin B) acetate has an MIC of 30 μg/ml against E. coli ATCC 25922.
Lactoferrin 17-41 acetate significantly stimulates apoptosis of HT-29 cells and displays cytotoxic activity on HT-29 cells.
Lactoferrin 17-41 acetate variously regulats transcription of genes involved in the p53 signaling pathway, such as PMAIP-1, TP5313, and SFN.
Lactoferrin 17-41 acetate can bind LPS from Gram-negative bacteria and that it can inhibit LPS induced cytokine response in human monocytic cells.
Cell Viability Assay
Cell Line:
HT-29 cells
Concentration:
50, 100, 200, 400, 800 or 1000 µg/mL
Incubation Time:
4, 12, 24 or 48 hours
Result:
More effective at inducing apoptosis at 400 µg/mL. Higher toxicity is shown at 800 µg/mL.
运输条件
Room temperature in continental US; may vary elsewhere.