Quercetagetin (6-Hydroxyquercetin) is a flavonoid. Quercetagetin is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50, 0.34 μM). Anti-inflammatory and anticancer properties.
体外研究
Quercetagetin also inhibits PIM2, PKA, and RSK2 with IC50s of 3.45, 21.2, and 2.82 µM, respectively.
Quercetagetin (0.1, 1, 10, and 100 μM, 72 hours) inhibits growth of RWPE2 prostate cancer cells with average ED50 is 3.8 μM.
Cell Viability Assay
Cell Line:
RWPE2 prostate cancer cells
Concentration:
0.1, 1, 10, and 100 μM
Incubation Time:
72 hours
Result:
Inhibited growth of RWPE2 prostate cancer cells with average ED50 is 3.8 μM.
体内研究
Quercetagetin significantly inhibits UVB-induced skin cancer development. Topical application of 4 or 20 nmol of Quercetagetin to mouse skin reduces tumor incidence by 32.0% and 46.7%, respectively.
Animal Model:
SKH-1 hairless mice model
Dosage:
4 or 20 nmol
Administration:
Topical application; 28 weeks
Result:
Inhibited UVB-induced skin tumorigenesis in SKH-1 hairless mice models. Delayed the development of tumors and reduced tumor volumes in an SKH-1 hairless mice model.
分子式
C15H10O8
分子量
318.24
CAS号
90-18-6
中文名称
栎草亭;六羟黄酮;六羟基黄酮
运输条件
Room temperature in continental US; may vary elsewhere.