Loxiglumide is a cholecystokinin (CCK-1) receptor antagonist.
IC50&Target
CCK-1 receptor
体内研究
The effects of pancreatic rest by oral administration of CCK-1 receptor antagonist Loxiglumide and pancreas stimulation are investigated via endogenous CCK release induced by po protease inhibitor camostat on the recovery of pancreatic secretory function, and biochemical and histological changes of the pancreas after acute hemorrhagic pancreatitis. Oral administration of CCK-1 receptor antagonist Loxiglumide with a dose of 50 mg/kg body weight inhibits pancreatic exocrine secretion for more than 12 h. Thus, every 12-h administration of Loxiglumide might have completely blocks the effect of endogenously released CCK on the pancreas (pancreatic rest).
分子式
C21H30N2O5Cl2
分子量
461.38
CAS号
107097-80-3
中文名称
氯谷胺
运输条件
Room temperature in continental US; may vary elsewhere.