KKL 顾客使用本产品发表的 0 篇科研文献

Motilin (26-47), human, porcine is an endogenous motilin receptor ligand with K_i and EC₅₀ of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line.

[Bpa,Ile]motilin is a full agonist at the motilin receptor that increases intracellular calcium in a concentration-dependent manner (EC₅₀ = 1.5 ± 0.4 nM). Motilin binds with high affinity (IC₅₀ 0.7± 0.2 nM) to receptors on smooth muscle cells. Motilin selectively activates G(q) and G(13), stimulates G alpha(q)-dependent phosphoinositide (PI) hydrolysis and 1,4,5-trisphosphate (IP(3))-dependent Ca release, and increases cytosolic free Ca. Motilin induces a biphasic, concentration-dependent contraction (EC₅₀ = 1.0 +/- 0.2 nM), consisting of an initial peak followed by a sustained contraction.

Room temperature in continental US; may vary elsewhere.