KKL 顾客使用本产品发表的 1 篇科研文献

Nisoxetine hydrochloride is a potent and selective inhibitor of noradrenaline transporter (NET), with a K_d of 0.76 nM. Nisoxetine hydrochloride is an antidepressant and local anesthetic, it can block voltage-gated sodium channels.

Kd: 0.76 nM (NET)

Nisoxetine inhibits [H]Nisoxetine binding to rat frontal cortical membranes with a K_i of 1.4±0.1 nM.
Nisoxetine inhibits [H]Noradrenaline uptake into rat frontal cortical synaptosomes with a K_i of 2.1±0.3 nM.
Nisoxetine inhibits Na currents with IC₅₀s of 1.6 and 28.6 µM at the membrane potential of -70 and -100 mV, respectively.

Nisoxetine (0.6-2.2 µM; a single intrathecal injection) displays dose-dependent effects on spinal anesthesia in rats.
Nisoxetine (2.2 µM; a single intrathecal injection) shows 100, 100, and 100% of blockades in motor function, proprioception, and with duration of action of about 61, 96, and 236 min, respectively.

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