GLP-1(7-37) (0.5, 5 or 50 pmol/min/kg) infused during the second hour of a 2-hour 11-mM hyperglycemic clamp produces a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion in rats.
Infusion of GLP-1(7-37) (5 pmol/min/kg) from 1 hour through 7 hours produces a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle in rats with maintained glucose concentration at 11 mM.
Animal Model: |
Male Sprague-Dawley rats weighing 300 to 350 g with glucose IV at a variable
rate for 7 hours to maintain plasma glucose concentration at 11 mM.
|
Dosage: |
5 pmol/min/kg. |
Administration: |
IV from 1 hour through 7 hours. |
Result: |
Produced a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle. |
Animal Model: |
Male Sprague-Dawley rats weighing 300 to 350 g with maintained plasma glucose concentration at 11 mM.
|
Dosage: |
0.5, 5 or 50 pmol/min/kg. |
Administration: |
IV during the second hour of a 2-hour 11-mmol/L hyperglycemic clamp. |
Result: |
Produced a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion. |