Orexin 2 Receptor Agonist is a potent (EC50 on OX2R is 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio is 70) agonist.
IC50 value: 23 nM (EC50)
Target: Orexin 2 Receptor
Orexin 2 Receptor Agonist shows not only potent
activity but also high selectivity for OX2R over OX1R. In CHO cells overexpressing hOX1R and HEK-293 cells overexpressing hOX2R, compound 26 displaced [125I]orexin-A in a concentration dependent manner: 26 bound to hOX2R and hOX1R with Ki of 0.14 and 0.77 μM, respectively.[1]
分子式
C32H34N4O5S
分子量
586.70
CAS号
1796565-52-0
运输条件
Room temperature in continental US; may vary elsewhere.