CWP232228 - CAS:1144044-02-9

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CWP232228

目录号 : KM12998 CAS No. : 1144044-02-9 纯度 : 98%

Data Sheet 产品使用指南

CWP232228 是一种高效的选择性 Wnt/β-catenin 信号通路抑制剂，在细胞核中，拮抗 β-catenin 与 T 细胞因子 (TCF) 结合。CWP232228 通过抑制乳腺癌和肝癌干细胞 (CSCs) 的生长来抑制肿瘤的形成和转移而无毒性。

规格	价格	是否有货
5mg		In-stock
10mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

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Other Forms of Rapamycin:

β-catenin/CBP-IN-1 In-stock
1H-Pyrazole-4-carboxamide, 5-methyl-1-phenyl-N-2-quinolinyl- In-stock
Gossypolone In-stock
PRI-724 In-stock
SRI 37892 In-stock

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生物活性

CWP232228, a highly potent selective Wnt/β-catenin signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 suppresses tumor formation and metastasis without toxicity through the inhibition of the growth of breast and liver cancer stem cells (CSCs).

体外研究

CWP232228 (0.01-100 μM; 48 hours) inhibits cell proliferation with IC₅₀ values are 2 and 0.8 μM in mouse (4T1) and human (MDA-MB-435) breast cancer cell lines, respectively.
CWP232228 (0.01-10 μM; 48 hours) inhibits cell proliferation with IC₅₀s of 2.566, 2.630, and 2.596 μM in Hep3B, Huh7 and HepG2 cells, respectively.

Cell Proliferation Assay

Cell Line:	Mouse (4T1) and human (MDA-MB-435) breast cancer cell lines
Concentration:	0.01, 0.1, 1, 10, 100 μM
Incubation Time:	48 hours
Result:	IC₅₀s were 2 and 0.8 μM for 4T1 and MDA-MB-435 cell lines, respectively.

Cell Proliferation Assay

Cell Line:	Hepatocellular carcinoma cell lines HepG2, Huh7, and Hep3B
Concentration:	0.01, 0.1, 0.5, 1, 5, 10 μM
Incubation Time:	48 hours
Result:	IC₅₀s were 2.566, 2.630, and 2.596 μM for Hep3B, Huh7 and HepG2 cells, respectively.

体内研究

CWP232228 (100 mg/kg, administered i.p.; daily; 21days for mice bearing 4T1 cell tumors; 60 days for mice bearing MDA-MB-435 cell tumors) results in a significant reduction in tumor volume.

Animal Model:	7-week-old female Balb/c and NOD/SCID mice bearing 4T1 or MDA-MB-435 cell tumors
Dosage:	100 mg/kg
Administration:	Administered i.p.; daily; 21days for mice bearing 4T1 cell tumors, 60 days for mice bearing MDA-MB-435 cell tumors
Result:	Treatment resulted in a significant reduction in tumor volume.

分子式

C₃₃H₃₄N₇Na₂O₇P

分子量

717.62

CAS号

1144044-02-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : 62.5 mg/mL (87.09 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.3935 mL	6.9675 mL	13.9350 mL
5 mM	0.2787 mL	1.3935 mL	2.7870 mL
10 mM	0.1393 mL	0.6967 mL	1.3935 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

科研文献

纯度： 98%

Data Sheet

产品使用指南

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

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Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 2 篇科研文献

The molarity calculator equation

The dilution calculator equation