Terfenadine-d3 - CAS:192584-82-0

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Terfenadine-d3

目录号 : KM12895 CAS No. : 192584-82-0

Data Sheet 产品使用指南

Terfenadine-d3 ((±)-Terfenadine-d3) 是 Terfenadine 的氘代物。Terfenadine ((±)-Terfenadine) 是一种有效的 hERG 开放通道抑制剂, IC₅₀为 204 nM。Terfenadine 也是一种 H1 组胺受体 (histamine receptor) 拮抗剂，通过调节 Ca²⁺ 稳态在黑素瘤细胞中起到有效的细胞凋亡诱导作用。Terfenadine 诱导 ROS 依赖性细胞凋亡，同时激活 Caspase-4，-2，-9。

规格	价格	是否有货
2000μg	询价	In-stock
5mg	询价	In-stock
10mg	询价	In-stock
25mg	询价	In-stock

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Mebhydrolin napadisylate In-stock

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生物活性	Terfenadine-d3 ((±)-Terfenadine-d3) is the deuterium labeled Terfenadine. Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC₅₀ of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9.
体外研究	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
分子量	474.69
CAS号	192584-82-0
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.