Ac-DEVD-AMC 是一种 caspase-3/caspase-7 荧光底物。用细胞裂解物处理 Ac-DEVD-AMC 时，Ac-DEVD-AMC 会释放氨基-4-甲基香豆素 (AMC) 用于荧光检测，激发波长为 380 nm，发射波长为 460 nm。
| 生物活性 |
Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm. |
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| 体外研究 |
Ac-DEVD-AMC is the caspase-3 substrate and could be used to monitor intracellular caspase-3 activity.The AMC moiety is highest at 2 h (area =5.6±1.8), the AMC peak area for Ac-DEVD-AMC incubated without lung specimen (substrate alone) for 6 h is relatively small. |
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| 分子式 |
C30H37N5O13
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| 分子量 |
675.64
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| CAS号 |
169332-61-0
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Protect from light
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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| 溶解性数据 |
In Vitro:
H2O : 0.67 mg/mL (0.99 mM; Need ultrasonic) |
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| 科研文献 |
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