BD-1047 (dihydrobromide) is a selective functional antagonist of sigma-1 receptor, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia.
IC50&Target
sigma-1 receptor
体外研究
BD-1047 (dihydrobromide) prevents that Cutamesine reduces the cell death rate induced by light exposure in murine photoreceptor-derived 661w cells.
BD-1047 (dihydrobromide) attenuates that Cutamesine reduces the mitochondrial damage and the elevated level of caspase 3/7 activity.
体内研究
BD-1047 (dihydrobromide) (1-10 mg/kg; i.p.) decreases the Apomorphine (APO)-induced climbing behavior at the dose of 10 mg/kg in mice.
BD-1047 (dihydrobromide) counteracts the antidepressant-like effect induced by co-administration of pramipexole and sertraline (but not pramipexole and fluoxetine).
BD-1047 (dihydrobromide) reduces the increasing expression of pNR1, and reverses the Sig-1 R agonists potentiated NMDA-induced pain behaviour and pNR1 immunoreactivity.
Animal Model:
Male Albino Swiss mice (50 days old, 25–28 g)
Dosage:
1 mg/kg, 3 mg/kg, 10 mg/kg
Administration:
Intraperitoneal injection
Result:
Decreased the APO-induced climbing at the dose of 10 mg/kg in mice.
分子式
C13H22Br2Cl2N2
分子量
437.04
CAS号
138356-21-5
运输条件
Room temperature in continental US; may vary elsewhere.