Dimemorfan phosphate - CAS:36304-84-4

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Dimemorfan phosphate (Synonyms:二甲啡烷磷酸盐；磷酸二甲啡烷)

目录号 : KM12506 CAS No. : 36304-84-4 纯度 : 98%

Data Sheet 产品使用指南

Dimemorfan phosphate 是 sigma 1 receptor 的有效激动剂，能够有效止咳。

规格	价格	是否有货
50mg		In-stock
100mg		In-stock
200mg	询价	In-stock
500mg	询价	In-stock

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Ginkgolide J In-stock
Ginkgolide K In-stock
THK-5470 In-stock
NH-3 In-stock
Velufenacin In-stock

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生物活性

Dimemorfan phosphate is a sigma 1 receptor agonist, used as a potent antitussive.

体外研究

Dimemorfan (5-20 μM) inhibits both fMLP- and PMA-induced ROS production in a concentration-dependent manner and is relatively more potent in inhibiting fMLP-induced ROS production with an IC₅₀ value of 7.0 μM. Dimemorfan (10-50 μM) does not display significant activity in scavenging free radicals by xanthine/xanthine oxidase system. Dimemorfan significantly suppressed Mac-1 upregulation both in PMA- and fMLP-activated groups. Dimemorfan (10-20 μM) significantly suppresses LPS-induced ROS and NO production, and suppresses LPS-induced iNOS protein expression, and both the percentage of the positively stained population and the MCF intensities of MCP-1 and TNF-α in BV2 cytosol. Dimemorfan (20 μM) significantly blocks the degradation of cytosolic Iκ-Bα and nuclear translocation of NF-κB p65, as well as the transcriptional activity of NF-κB.

体内研究

Dimemorfan (6.25 or 12.5 mg/kg, s.c.) significantly attenuates the BAY k-8644-induced convulsive behaviors, in a dose-related manner (6.25 mg/kg dimemorfan+BAY k-8644 or 12.5 mg/kg dimemorfan+BAY k-8644 versus Saline+BAY k-8644, P<0.05 and P<0.01, respectively). Dimemorfan significantly attenuates BAY k-8644-induced increases in the c-fos and c-jun protein expression in a dose-dependent manner. Dimemorfan does not significantly affect locomotor activity or produce significant circling behavior in any locomotor pattern in mice. Dimemorfan (1 and 5 mg/kg, i.p.) surpresses the incarease of the plasma levels of TNF-α in mice. The infiltration of neutrophils into lung and liver as well as the production of oxidative stress (EB staining) in these tissues induced by LPS is markedly inhibited by the treatment with dimemorfan.

分子式

C₁₈H₂₅N^.H₃O₄P

分子量

353.39

CAS号

36304-84-4

中文名称

二甲啡烷磷酸盐；磷酸二甲啡烷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : 10 mg/mL (28.30 mM; ultrasonic and warming and heat to 60°C)

DMSO : 1 mg/mL (2.83 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.8297 mL	14.1487 mL	28.2973 mL
5 mM	0.5659 mL	2.8297 mL	5.6595 mL
10 mM	0.2830 mL	1.4149 mL	2.8297 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： 98%