Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 adhesion.
IC50&Target
IC50: 7 nM (calcineurin)
体外研究
Cyclosporin A is able to bind with the cyclophilin in T cells. Cyclosporin A works by forming a Cyclophilin-Cyclosporin A complex to inhibit calcineurin. Cyclosporin A inhibits calcineurin in stimulated cells with an IC50 value of 7 nM. Cyclosporin A suppresses the nuclear translocation of NF-AT. Cyclosporin A shows an effect on mitochondria via preventing the MTP from opening with an IC50 of 39 nM.
体内研究
Cyclosporin A has immunosuppressive activity, and is active via parenteral and p.o. administration in mice, rat and guinea pigs. Cyclosporin A can be used in organ transplantation to prevent rejection.
分子式
C62H111N11O12
分子量
1202.61
CAS号
59865-13-3
中文名称
环孢霉素A;环孢素A;环孢多肽A;环孢灵;赛斯平;环孢素
运输条件
Room temperature in continental US; may vary elsewhere.