BGC-20-1531 (PGN 1531) free base is a potent and selective prostanoid EP4 receptor antagonist, with a pKB of 7.6. BGC-20-1531 free base has the potential for the research of migraine headache.
IC50&Target
EP4
3 nM (Ki)
体外研究
BGC-20-1531 free base competitively antagonized PGE2-induced vasodilatation of human middle cerebral (pKb=7.8) and meningeal (pKb=7.6) arteries, but had no effect on responses induced by PGE2 on coronary, pulmonary or renal arteries.
体内研究
BGC-20-1531 free base (1-10 mg/kg; i.v.) causes a dose-dependent antagonism of the PGE2-induced increase in canine carotid blood flow.
Animal Model:
Beagle dogs
Dosage:
1-10 mg/kg
Administration:
I.v.
Result:
Caused a dose-dependent antagonism of the PGE2-induced increase in canine carotid blood flow.
分子式
C26H24N2O6S
分子量
492.54
CAS号
736183-35-0
运输条件
Room temperature in continental US; may vary elsewhere.