Azelastine hydrochloridem, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine hydrochloride can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2.
IC50&Target
H1 Receptor
体外研究
Azelastine hydrochloride can significantly inhibit HNEpC proliferation, and therefore, be helpful in against airway remodeling.
Cell Proliferation Assay
Cell Line:
Human nasal epithelial cells (HNEpC)
Concentration:
100 μM, 400 μM
Incubation Time:
21 days
Result:
Inhibited HNEpC growth.
Western Blot Analysis
Cell Line:
Human nasal epithelial cells (HNEpC)
Concentration:
100 μM
Incubation Time:
7 days
Result:
Significantly up-regulated the H1R, M1R and M3R levels.
体内研究
Azelastine hydrochloride (4 mg/kg; p.o.; daily; for 8 weeks) significantly reduces blood glucose, HbA1c and serum alkaline phosphatase (ALP), osteocalcin and downregulates apolipoprotein B in diabetic hyperlipidemic rats model.
Azelastine hydrochloride (4 mg/kg; p.o.; daily; for 8 weeks) improves the lipid profile (LDL-c decrease and HDL-c increase) in diabetic hyperlipidemic rats model.
Azelastine hydrochloride (4 mg/kg; p.o.; daily; for 8 weeks) attenuates calcium deposition and aortic calcification in diabetic hyperlipidemic rats model.
Animal Model:
Male albino Wistar rats (150-170 g), diabetic hyperlipidemic rats model
Dosage:
4 mg/kg
Administration:
Oral administration, daily, for 8 weeks
Result:
Ameliorated aortic calcification and increased apolipoprotein A expression along with a decline in apolipoprotein B.
分子式
C22H24N3OCl.HCl
分子量
418.36
CAS号
79307-93-0
中文名称
盐酸氮卓斯汀;盐酸氮斯丁
运输条件
Room temperature in continental US; may vary elsewhere.