Chebulinic acid - CAS:18942-26-2

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Chebulinic acid (Synonyms:诃子林鞣酸)

目录号 : KM12120 CAS No. : 18942-26-2 纯度 : 98%

Data Sheet 产品使用指南

Chebulinic acid 是一个天然的M. tuberculosis DNA gyrase抑制剂，也能抑制SMAD-3 phosphorylation和H+ K+-ATPase的活性。

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生物活性	Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.
体外研究	In vitro: binding of Chebulinic acid causes displacement of catalytic Tyr129 away from its target DNA-phosphate molecule. [1] Chebulinic acid reduce the expression and activity of MMP-2 at an ED50 value of 100 μM. EMT (Epithelial to Mesenchymal Transition) is found to be induced in ARPE-19 cells, through SMAD-3 phosphorylation and it is inhibited by CA. [2] chebulinic acid significantly inhibited H+ K+-ATPase activity in vitrowith IC50 of 65.01 μg/ml. [3]
分子式	C₄₁H₃₂O₂₇
分子量	956.68
CAS号	18942-26-2
中文名称	诃子林鞣酸
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
科研文献	•J Chromatogr A. 24 December 2021, 462784.