Recombinant Human HIF1A Protein, N-His expressed in E. coli, spanning Asp55-Val342. Purity: >90% by SDS-PAGE.
| 生物活性 |
Recombinant Human HIF1A Protein, N-His expressed in E. coli, spanning Asp55-Val342. Purity: >90% by SDS-PAGE. |
|---|---|
| 中文名称 |
Hypoxia-inducible factor 1-alpha, HIF-1-alpha, HIF1-alpha, ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, Class E basic helix-loop-helix protein 78, bHLHe78, Member of PAS protein 1, PAS domain-containing protein 8, HIF1A, BHLHE78, MOP
|
| 运输条件 |
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 储存方式 |
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 研究背景 |
Hypoxia-inducible factor 1-alpha (HIF1A) is a ~92 kDa protein. Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300.
|
| 种属 |
Homo sapiens (Human)
|
| 表达系统 |
E. coli
|
| Accession号 |
Q16665
|
| 蛋白长度 |
Asp55-Val342
|
| 应用 |
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
|
| 预测分子量 |
35.61 kDa
|
| 性状 |
Lyophilized
|
| 保存溶液 |
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
|
| 纯度 |
>90% as determined by SDS-PAGE.
|
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