Recombinant Human TEAD2 Protein, N-His expressed in E. coli, spanning Ala217-Asp447. Purity: >90% by SDS-PAGE.
| 生物活性 |
Recombinant Human TEAD2 Protein, N-His expressed in E. coli, spanning Ala217-Asp447. Purity: >90% by SDS-PAGE. |
|---|---|
| 运输条件 |
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 储存方式 |
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 研究背景 |
Transcriptional enhancer factor TEF-4 (TEAD2) is a ~49 kDa protein. Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development.
|
| 种属 |
Homo sapiens (Human)
|
| 表达系统 |
E. coli
|
| Accession号 |
Q15562
|
| 蛋白长度 |
Ala217-Asp447
|
| 应用 |
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
|
| 预测分子量 |
28.55 kDa
|
| 性状 |
Lyophilized
|
| 保存溶液 |
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
|
| 纯度 |
>90% as determined by SDS-PAGE.
|
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