KKL 顾客使用本产品发表的 24 篇科研文献

Cilengitide (EMD 121974) is a potent and selective inhibitor of the integrins α_νβ₃ and α_νβ₅. Cilengitide inhibits binding of isolated α_νβ₃ and α_νβ₅ to Vitronectin with an IC₅₀ value of 4 and 79 nM, respectively .

Cilengitide is a cyclized RGD (Arg-Gly-Asp motif)-containing pentapeptide. Cilengitide blocks integrin ανβ3- and ανβ5-mediated endothelial cell attachment and migration.
Cilengitide inhibits integrin-mediated binding to Vitronectin with IC₅₀'s of 0.4 and 0.4 μM in cell adhesion studies assessing the human melanoma M21 or UCLA-P3 human lung carcinoma cell lines .
Cilengitide inhibits the attachment of human umbilical vein endothelial cells to Vitronectin with an IC₅₀ of 2 μM .

Cilengitide (i.p. at 10, 50, and 250 μg three times per week) inhibits M21-L melanoma tumors growth in nude mice .

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