7,8-Dihydroneopterin - CAS:1218-98-0

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7,8-Dihydroneopterin (Synonyms:7,8-二氢-D-新蝶呤)

目录号 : KM11394 CAS No. : 1218-98-0

Data Sheet 产品使用指南

7,8-Dihydroneopterin 是一种炎症标记，通过增强一氧化氮合酶 (iNOS) 的表达来诱导星形胶质细胞和神经元细胞凋亡 (apoptosis)。可用于神经退行性疾病的研究。

规格	价格	是否有货	数量
5mg		In-stock
10mg		In-stock

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生物活性

7,8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases.

体外研究

7,8-Dihydroneopterin is a heterocyclic pteridine which produced and secreted by monocytes/macrophages upon stimulation with the cytokine interferon-y (IFN-y).
7,8-Dihydroneopterin (0.1, 0.5, 1, 2.5, 5 mM; 2 days and 5 days) inhibits growth of U373MG astroeytes .

Cell Viability Assay

Cell Line:	Astrocytic cell line U373MG
Concentration:	0.1, 0.5, 1, 2.5, 5 mM
Incubation Time:	2 days and 5 days
Result:	After 2 days of treatment, a significantly lower cell number was observed for those cells treated with 5 mM and 2.5 mM. After incubation for 5 days concentrations of 1-5 mM completely abrogated acid phosphatase activity to background level found for complete cell culture medium. A significant cell growth inhibition was also visible for the cells incubated with 0.5 mM, whereas 0.1 mM did not alter cell growth.

分子式

C₉H₁₃N₅O₄

分子量

255.23

CAS号

1218-98-0

中文名称

7,8-二氢-D-新蝶呤

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet

产品使用指南

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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