7,8-Dihydroneopterin (Synonyms:7,8-二氢-D-新蝶呤)
目录号 : KM11394 CAS No. : 1218-98-0 纯度 : 98%

7,8-Dihydroneopterin 是一种炎症标记,通过增强一氧化氮合酶 (iNOS) 的表达来诱导星形胶质细胞和神经元细胞凋亡 (apoptosis)。可用于神经退行性疾病的研究。

规格 价格 是否有货 数量
5mg
In-stock
10mg
In-stock

Other Forms of Rapamycin:

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生物活性

7,8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases.

IC50&Target

Apoptosis; iNOS

体外研究

7,8-Dihydroneopterin is a heterocyclic pteridine which produced and secreted by monocytes/macrophages upon stimulation with the cytokine interferon-y (IFN-y).
7,8-Dihydroneopterin (0.1, 0.5, 1, 2.5, 5 mM; 2 days and 5 days) inhibits growth of U373MG astroeytes .

Cell Viability Assay

Cell Line: Astrocytic cell line U373MG
Concentration: 0.1, 0.5, 1, 2.5, 5 mM
Incubation Time: 2 days and 5 days
Result: After 2 days of treatment, a significantly lower cell number was observed for those cells treated with 5 mM and 2.5 mM.
After incubation for 5 days concentrations of 1-5 mM completely abrogated acid phosphatase activity to background level found for complete cell culture medium.
A significant cell growth inhibition was also visible for the cells incubated with 0.5 mM, whereas 0.1 mM did not alter cell growth.
分子式
C9H13N5O4
分子量
255.23
CAS号
1218-98-0
中文名称
7,8-二氢-D-新蝶呤
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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