(Rac)-Indoximod (1-Methyl-DL-tryptophan) 是吲哚胺-2,3-双加氧酶 (IDO) 抑制剂。(Rac)-Indoximod 和 IFN-γ 联用显著降低了表达 α-SMA 的人心肌成纤维细胞活性，并通过上调 IRF-1，Fas 和 FasL 基因诱导凋亡(apoptosis)。
| 生物活性 |
(Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes. |
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| 体外研究 |
(Rac)-Indoximod (1-Methyl-DL-tryptophan; 0.5 mM; 3 days) inhibits tryptophan depletion, thereby partially reversing the growth-inhibitory activity of IFN-γ, but eventually induces cell death regardless of tryptophan depletion. Cell Viability Assay
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| 分子式 |
C12H14N2O2
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| 分子量 |
218.25
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| CAS号 |
26988-72-7
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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| 溶解性数据 |
In Vitro:
H2O : 2.5 mg/mL (11.45 mM; ultrasonic and warming and adjust pH to 10 with NaOH and heat to 60°C) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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