(Rac)-Indoximod - CAS:26988-72-7

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(Rac)-Indoximod (Synonyms:1-Methyl-DL-tryptophan; (Rac-NLG-8189))

目录号 : KM11351 CAS No. : 26988-72-7 纯度 : 98%

Data Sheet 产品使用指南

(Rac)-Indoximod (1-Methyl-DL-tryptophan) 是吲哚胺-2,3-双加氧酶 (IDO) 抑制剂。(Rac)-Indoximod 和 IFN-γ 联用显著降低了表达 α-SMA 的人心肌成纤维细胞活性，并通过上调 IRF-1，Fas 和 FasL 基因诱导凋亡(apoptosis)。

规格	价格	是否有货
50mg		In-stock
100mg	询价	In-stock
200mg	询价	In-stock

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生物活性

(Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes.

体外研究

(Rac)-Indoximod (1-Methyl-DL-tryptophan; 0.5 mM; 3 days) inhibits tryptophan depletion, thereby partially reversing the growth-inhibitory activity of IFN-γ, but eventually induces cell death regardless of tryptophan depletion.

Cell Viability Assay

Cell Line:	Human cardiac myofibroblasts (hCMs)
Concentration:	0.5 mM
Incubation Time:	3 days
Result:	Growth retardation by IFN-γ was partially reversed on day 2, but cell viability was further reduced on day 3.

分子式

C₁₂H₁₄N₂O₂

分子量

218.25

CAS号

26988-72-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

H₂O : 2.5 mg/mL (11.45 mM; ultrasonic and warming and adjust pH to 10 with NaOH and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.5819 mL	22.9095 mL	45.8190 mL
5 mM	0.9164 mL	4.5819 mL	9.1638 mL
10 mM	0.4582 mL	2.2910 mL	4.5819 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： 98%