KKL 顾客使用本产品发表的 1 篇科研文献

FGH10019 is a novel sterol regulatory element-binding protein (SREBP) inhibitor with IC₅₀ of 1 μM.

Treatment of the CHO-K1 cells with analog FGH10019 decreases the percentage of the mature form of SREBP-2 (68 kDa) at lower concentrations than treatment with fatostatin. Densitometric analysis of the gels indicates that the IC₅₀ of analog FGH10019 is approximately 1 μM, which is 5-10 times lower than the IC₅₀ of fatostatin (appr 10 μM).

FGH10019-treated chow is fed at a dose rate calculated to provide about 0.7 mg analog FGH10019 per day, at about 23 mg/kg body weight, to 5-wk-old male ob/ob mice weighing an average of appr 30 g. After 8 wk on the analog 24-treated chow, the mice gain 8-9 % less weight than control mice.

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