21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione
目录号 : KM11278 CAS No. : 37413-91-5 纯度 : 98%

21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione 是 delta 9,11 类固醇类合成的中间体 (intermediate),如 Vamorolone 。delta 9,11 steroids 是糖皮质激素的修饰后的产物,具有抗炎 (anti-inflammatory) 特性。delta 9,11 类固醇类可以用作保护细胞损伤(脂质过氧化)和抑制新生血管的试剂。

规格 价格 是否有货 数量
10mg
In-stock
25mg
In-stock
50mg 询价 In-stock
100mg 询价 In-stock
KKL Med 的所有产品和服务仅用于科学研究,不能被用于人体,兽医,我们也不向个人提供产品和服务。
生物活性

21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione is an intermediate of delta 9,11 steroids synthesis, for example, Vamorolone . The delta 9,11 steroids are modifications of glucocorticoids and has anti-inflammatory properties. The delta 9,11 steroids are agents for protection against cell damage (lipid peroxidation) and inhibition of neovascularization.

体外研究

Δ9,11 derivatives are designed and developed to stably incorporate into cell membranes and inhibit lipid peroxidation without glucocorticoid or mineralocorticoid activities, thus avoiding side effects associated with traditional corticosteroids.
VBP15 acts as a lead compound due to potent NF-κB inhibition and GR translocation similar to prednisone and dexamethasone, lack of transactivation properties, and good bioavailability.

分子式
C23H26O4
分子量
366.45
CAS号
37413-91-5
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (272.89 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7289 mL 13.6444 mL 27.2889 mL
5 mM 0.5458 mL 2.7289 mL 5.4578 mL
10 mM 0.2729 mL 1.3644 mL 2.7289 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
在线客服
咨询热线
400-881-9290
关注微信公众号