AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator. AZD2423 has an IC50 of 1.2 nM for CCR2 Ca flux .
体外研究
AZD2423 inhibits MCP-1 induced calcium mobilization and chemotaxis of THP-1 cell line with an IC50 of 4 nM.
分子式
C20H29ClFN5O2
分子量
425.93
CAS号
1229603-37-5
运输条件
Room temperature in continental US; may vary elsewhere.