AZD9567 (compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation.
IC50&Target
IC50: 3.8 nM (Glucocorticoid receptor).
体内研究
AZD9567 (15 mg/kg/day, Oral gavage daily for 8 days) treatment shows excellent in vivo efficacy in a rat model of joint inflammation.
Animal Model:
Antigen-induced joint inflammation model in female Lewis rats (175-200 g), sensitized by an intra-articular injection of 5 μg of SCW.
Dosage:
15 mg/kg/day.
Administration:
Oral gavage daily for 8 days.
Result:
Inhibited ankle swelling in the rat SCW model.
分子式
C27H28F2N4O3
分子量
494.53
CAS号
1893415-00-3
运输条件
Room temperature in continental US; may vary elsewhere.