NBI-31772 hydrate 是胰岛素样生长因子 IGF 与 IGFBP 相互作用的有效抑制剂。NBI-31772 hydrate 也是一种非肽类配体，可从其结合蛋白复合物 IGF-I/IGFBP-3 中释放生物活性 IGF-I (对六种人类亚型的 Ki=1-24 nM) 。具有抗焦虑和抗抑郁作用。
| 生物活性 |
NBI-31772 hydrate is a potent inhibitor of interaction between insulin-like growth factor (IGF) and IGF-binding proteins (IGFBPs). NBI-31772 hydrate is also a nonpeptide ligand that releases bioactive IGF-I from the IGF-I/IGFBP-3 complex (Kis=1-24 nM for all six human subtypes). Anxiolytic and antidepressant-like effects. |
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| 体内研究 |
NBI-31772 (5-100 μg; icv; immediately or at 1, 2, or, 3 hours after MCAO) at the time of ischemia onset also dose-dependently reduced infarct size, and the highest dose (100 μg) significantly reduced both total and cortical infarct volume.
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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