Lactacystin 是一种抗生素，链霉菌属的代谢物，是一种有效的选择性蛋白酶体 (proteasome) 抑制剂，对 20S 蛋白酶体的 IC50 为 4.8 μM。Lactacystin 还抑制溶酶体酶组织蛋白酶 A。Lactacystin 抑制细胞生长并诱导神经突增生。
| 生物活性 |
Lactacystin, an antibiotic Streptomyces spp. metabolite, is a potent and selective proteasome inhibitor with an IC50 of 4.8 μM for 20S proteasome. Lactacystin also inhibits the lysosomal enzyme cathepsin A. Lactacystin inhibits cell growth and induces neurite outgrowth. |
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| 体内研究 |
Lactacystin (microinjection; 2 µg) induces a Parkinson’s disease-like motor phenotype 5-7 days after injection in young and adult mice.
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| 分子式 |
C15H24N2O7S
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| 分子量 |
376.43
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| CAS号 |
133343-34-7
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| 中文名称 |
蛋白酶体抑制剂
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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