IRL-1620 TFA - KKL Med Inc.

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IRL-1620 TFA

目录号 : KM10660 纯度 : 95%

Data Sheet 产品使用指南

IRL-1620 (TFA) 是高效，选择性的内啡肽受体 (endothelin receptor) B 型激动剂，K_i 值为 16 pM。

规格	价格	是否有货
500μg		In-stock
1mg		In-stock
5mg		In-stock
10mg	询价	In-stock
50mg	询价	In-stock

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KKL Med 的所有产品和服务仅用于科学研究，不能被用于人体，兽医，我们也不向个人提供产品和服务。

生物活性

IRL-1620 (TFA) is a potent and selective endothelin receptor type B (ETB) agonist with a K_i of 16 pM.

体外研究

IRL-1620 (TFA) is the most potent and specific ligand for the ETB receptor (K_iETA/ K_iETB=120,000) as judged by the K_i values for ETA (19 μM) and ETB (16 PM) receptors.
IRL-1620 (TFA) is 60 times more selective for the ETB receptor than ET-3 (K_iETA/ K_iETB=1,900).

体内研究

IRL-1620 (TFA) (1-100 nM) induces contractions of the guinea pig trachea. The effective concentration that produces 30 % of 60 mM KCI-induced contraction is estimated to be 28 nM for IRL-1620.
IRL-1620 (TFA) (1-100 nM) increases cytosolic Ca in the vascular endothelium ([Ca]E) with little effect on resting muscle tone, and relaxes the norepinephrine-stimulated tone with an increase in [Ca]E, in rat aorta,.
IRL-1620 (TFA) improves both acquisition (learning) and retention (memory) on the water maze task and enhances angiogenic and neurogenic remodeling. Rats treated with IRL-1620 significantly reduces the cognitive impairment induced by Aβ. IRL-1620 treatment enhances the number of blood vessels labeled with VEGF compared to vehicle treatment.
IRL-1620 (TFA), restores analgesic tolerance to morphine and oxycodone, but it does not affect morphine and oxycodone induced decrease in NGF/PI3K expression. IRL-1620 attenuates opioid tolerance without the involvement of NGF/PI3K pathway.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Protect from light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 100 mg/mL (51.68 mM; Need ultrasonic)

H₂O : < 0.1 mg/mL (ultrasonic) (insoluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.5168 mL	2.5840 mL	5.1680 mL
5 mM	0.1034 mL	0.5168 mL	1.0336 mL
10 mM	0.0517 mL	0.2584 mL	0.5168 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： 95%