18-Oxocortisol 是由醛固酮合酶 (CYP11B2) 产生的皮质醇衍生物。18-Oxocortisol 是天然存在的盐皮质激素 (mineralocorticoid) 激动剂。18-Oxocortisol 是肾上腺静脉采样中的生物标志物。
| 生物活性 |
18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). 18-Oxocortisol is a naturally occurring mineralocorticoid agonist. 18-Oxocortisol is a biomarker in adrenal vein sampling. |
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| 体内研究 |
Administration of 18-oxocortisol to rats induces a mineralocorticoid-type hypertension with hypokalemia, cardiac and renal enlargement and cardiovascular lesions. Administration of 18-oxocortisol to sheep also causes a rapid increase in blood pressure. However, the doses required for increasing blood pressure are high.
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| 分子式 |
C21H28O6
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| 分子量 |
376.44
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| CAS号 |
2410-60-8
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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客服小K 
客服小K
Data Sheet
