Firuglipel (DS-8500a) is an orally available, potent and selective GPR119 agonist.
IC50&Target
GPR119
体外研究
Firuglipel (DS-8500a) increases intracellular cAMP in a concentration-dependent manner in human, rat, and mouse GPR119-expressing Chinese hamster ovary (CHO)-K1 cells, with EC50 values of 51.5, 98.4, and 108.1 nM, respectively. DS-8500a has no effect on intracellular cAMP in pcDNA3.1/CHO-K1 cells.
体内研究
Firuglipel (DS-8500a) (1-30 mg/kg) upregulates glucagon-like peptide-1 and enhances glucose-dependent insulin secretion and improves glucose homeostasis in type 2 diabetic rats.
分子式
C25H26FN3O5
分子量
467.49
CAS号
1371591-51-3
运输条件
Room temperature in continental US; may vary elsewhere.