PF-4693627 - CAS:1312815-93-2

您当前的位置：

PF-4693627

目录号 : KM10430 CAS No. : 1312815-93-2 纯度 : 98%

Data Sheet 产品使用指南

PF-4693627 是一种有效的，口服生物可利用的，选择性的微粒体前列腺素E合酶 (mPGES-1) 抑制剂 (IC₅₀=3 nM)，可用于骨关节炎和类风湿关节炎等的研究。

规格	价格	是否有货	数量
10mg		In-stock

加入购物车大包装询价

Other Forms of Rapamycin:

Kgp-IN-1 hydrochloride In-stock
Ginkgolide A In-stock
Ginkgetin In-stock
VKGILS-NH2 In-stock
7,3',4'-Tri-O-methylluteolin In-stock

KKL Med 的所有产品和服务仅用于科学研究，不能被用于人体，兽医，我们也不向个人提供产品和服务。

生物活性

PF-4693627 is a potent, selective and orally bioavailable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor (IC₅₀=3 nM) for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA).

体外研究

PF-4693627 also inhibits mPGES-1 with IC₅₀s of 180 and 6 nM in HWB-1483 and human fetal fibroblast, respectively.
PF-4693627 shows high activity in lipopolysaccharide (LPS) stimulated human whole blood (HWB) cell assay (IC₅₀=109 nM).

体内研究

PF-4693627 (10 mg/kg; orally) inhibits 63% of PGE2 production relative to vehicle control in Guinea pig carrageenan stimulated air pouch model.
PF-4693627 (1.0 mg/kg; i.v.) shows good bioavailability (59%) and modest half life (t_1/2=3.7 h) in Sprague-Dawley rats.

Animal Model:	Guinea pig with carrageenan stimulated air pouch inflammation model
Dosage:	10 mg/kg
Administration:	Administered orally
Result:	63% PGE2 inhibition.

Animal Model:	Sprague-Dawley rats.
Dosage:	1.0 mg/kg (Pharmacokinetic Analysis)
Administration:	Administered i.v.
Result:	Clearance (CL), volume of distribution (Vd_ss), t_1/2, mean residence time (MRT) and bioavailability (F) is 12 mL/min/kg, 3.0 L/kg, 3.7 h, 4.42 h, 59%, respectively.

分子式

C₂₆H₂₉N₃O₃Cl₂

分子量

502.43

CAS号

1312815-93-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： 98%

Data Sheet

产品使用指南

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

联系我们

400-881-9290
technical-service@kklmed.com

terminal-order@kklmed.com

terminal-inspection@kklmed.com

dealer-order@kklmed.com
10338 stony run ln，ste121，ashland，va，23005，USA

客户服务

快速询价订购信息售后服务退货和退款销售通用条款 Literature Award

KKL MED 小分子

KKL MED

关注我们

获得KKL MED 最新资讯

Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 0 篇科研文献

The molarity calculator equation

The dilution calculator equation