Abeprazan (DWP14012) 是一种钾竞争性酸 (potassium-competitive acid) 阻滞剂。Abeprazan 通过可逆的钾竞争性离子结合抑制 H+，K+- ATPase，而无需酸激活。Abeprazan 是一种潜在的质子泵抑制剂，用于研究与酸相关的疾病。
| 生物活性 |
Abeprazan (DWP14012) is a potassium-competitive acid blocker. Abeprazan inhibits H, K- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases. |
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| 体外研究 |
The mechanism of action of Abeprazan is reversibly binding to H, K‐ATPase, and, unlike that of PPIs, does not require acidic environment for drug activation. |
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| 体内研究 |
DWP14012 inhibited acid secretion in a dose-dependent manner and the inhibition of gastric acid secretion was equal to or greater than that of vonoprazan, a previously approved P-CAB, in various in vivo studies using pylorus-ligated rats, lumen-perfused rat models and heidenhain pouch dog models.
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| 分子式 |
C19H17F3N2O3S
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| 分子量 |
410.41
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| CAS号 |
1902954-60-2
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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| 临床试验 |
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纯度： 98%
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