GSM-1 is a potent γ-secretase modulator. GSM-1 directly targets the transmembrane domain (TMD) 1 of presenilin 1 (PS1).
体外研究
GSM-1 increases the levels of Aβ38 produced from WT APP. GSM-1 potently loweres the levels of Aβ42 of WT APP and all the Phe mutants by ∼70–80%, even for the V44F mutant, which produced only extremely small amounts of Aβ42.
GSM-1 directly binds to the N-terminal fragment of PS1.
分子式
C26H31NO2F3Cl
分子量
481.98
CAS号
884600-68-4
运输条件
Room temperature in continental US; may vary elsewhere.