AZD-0284 is a selective inverse agonist of the nuclear receptor RORγ. AZD-0284 has the potential for plaque psoriasis vulgaris and respiratory tract disorders treatment.
IC50&Target
pIC50: 7.4 (FRET RORγ)
体外研究
AZD0284 (0.37 μM; 5 days) inhibits IL-17A production in human TH17 cells.
AZD0284 reduces polarization of TH17 into pathogenic TH17/1 cells. AZD0284 decreases frequency of single IL-17cell as well as double positive TH17/1 cells. AZD0284 reduces IL-17A secretion and RNA expression of IL-17A, IL-17F, IL-22 and IL-23R.
分子式
C21H18F6N2O5S
分子量
524.43
CAS号
2101291-07-8
运输条件
Room temperature in continental US; may vary elsewhere.