(Rac)-Modipafant (UK-74505) is an orally active, selective, long-acting irreversible platelet activating factor receptor (PAFR) antagonist. (Rac)-Modipafant prevents dengue infection.
体内研究
(Rac)-Modipafant (UK-74505) (10 mg/kg; p.o.; twice a day until day 10) prevents Severe Dengue Infection.
(Rac)-Modipafant exhibits highly selective, time-dependent inhibition of PAF-induced aggregation of rabbit washed platelets (IC50=26.3 and 1.12 nM after 0.25 and 60 min preincubation, respectively).
(Rac)-Modipafant (5-20 mg/kg; p.o.) dose-dependently inhibits the Zymosan -induced articular hyperalgesia.
Animal Model:
8- to 10-week-old BALB/c mice (DEN-2 strain infected)
Dosage:
10 mg/kg
Administration:
P.o.; twice a day (started on days 0, 3, 5, or 7) until day 10
Result:
Decreased by approximately 50% the lethality associated with DEN-2 infection.
Animal Model:
Male BALB/C (8- to 10- week-old) wild-type mice
Dosage:
5, 10 and 20 mg/kg
Administration:
P.o.
Result:
Dose-dependently inhibited the Zymosan -induced articular hyperalgesia.
分子式
C34H29N6O3Cl
分子量
605.09
CAS号
122956-68-7
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.