LY223982 is a potent and specific inhibitor of leukotriene B4 receptor, with an IC50 of 13.2 nM against [H]LTB4 binding to LTB4 receptor.
IC50&Target
LTB4
13.2 nM (IC50)
体外研究
LY223982 is a potent and specific inhibitor of leukotriene B4 (LTB4) receptor, with an IC50 of 13.2 nM against [3H]LTB4 binding to LTB4 receptor. LY223982 is also a potent antagonist of the aggregation of human neutrophils by LTB4 (IC50, 100 nM).
体内研究
LY223982 inhibits transient leukopenia induced in rabbits with LTB4 (ED50, 3 mg/kg) but not with FMLP, and shows no agonist activity in any of the test systems.
分子式
C30H30O7
分子量
502.56
CAS号
117423-74-2
运输条件
Room temperature in continental US; may vary elsewhere.