15-Deoxy-Δ-12,14-prostaglandin J2 - CAS:87893-55-8

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15-Deoxy-Δ-12,14-prostaglandin J2 (Synonyms:15d-PGJ2; 15-Deoxy-Δ12,14-PGJ2)

目录号 : KM10058 CAS No. : 87893-55-8 纯度 : ≥95%

Data Sheet 产品使用指南

15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) 是一种环戊烯酮前列腺素和 PGD2 的代谢产物。15-Deoxy-Δ-12,14-prostaglandin J2 是一种选择性的 PPARγ (EC₅₀ 为 2 µM) 和共价的 PPARδ 激动剂。15-Deoxy-Δ-12,14-prostaglandin J2 促进 C3H10T1/2 成纤维细胞向脂肪细胞的有效分化，EC₅₀ 为 7 μM。

规格	价格	是否有货
1mg		In-stock
5mg	询价	In-stock
10mg	询价	In-stock

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生物活性	15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC₅₀ of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC₅₀ of 7 μM.
体外研究	15-Deoxy-Δ12,14-PGJ2 (15d-PGJ2) is a cyclopentenone prostaglandin that features an electrophilic, α, β-unsaturated ketone (an enone) in the cyclopentenone ring. 15-Deoxy-Δ-12,14-prostaglandin J2 is one of the cyPGs whose functions in inflammation, cell proliferation, survival, and apoptosis have been documented. 15-Deoxy-Δ-12,14-prostaglandin J2 activates PPARδ in a dose-dependent manner. 15-Deoxy-Δ-12,14-prostaglandin J2 activates PPARδ’s transcriptional activity through formation of a covalent adduct between its endocyclic enone at C9 and Cys249 in the receptor’s ligand-binding domain.
分子式	C₂₀H₂₈O₃
分子量	316.43
CAS号	87893-55-8
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Solution, -20°C, 2 years
科研文献	•Research Square Preprint. 2020 Dec.