Delapril hydrochloride is an angiotensin-converting enzyme (ACE) inhibitor for the treatment of cardiovascular diseases.
体内研究
Delapril (3 mg/kg; administered orally for 2 weeks) exerts potent ACE inhibitory activity in spontaneously hypertensive rat (SHR) .
Delapril (1-10 mg/kg; orally) exerts a marked and long-lasting antihypertensive action in various experimental models of hypertension.
Animal Model:
SHR
Dosage:
3 mg/kg
Administration:
Administered orally; 2 weeks
Result:
Exerted potent ACE inhibitory activity.
Animal Model:
2-kidney, 1-clip hypertensive Rats, Dogs, and SHR
Dosage:
1-10 mg/kg
Administration:
Oral
Result:
Exerted a marked and long-lasting antihypertensive action.
分子式
C26H32N2O5ClH
分子量
489.00
CAS号
83435-67-0
中文名称
地拉普利盐酸盐
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder
-20°C
3 years
4°C
2 years
In solvent
-80°C
6 months
-20°C
1 month
溶解性数据
In Vitro:
DMSO : 250 mg/mL (511.25 mM; Need ultrasonic)
H2O : 1.72 mg/mL (3.52 mM; ultrasonic and warming and heat to 60°C)