NSC-23766
(Synonyms:N6-[2-[[4-(二乙基氨基)-1-甲基丁基]氨基]-6-甲基-4-嘧啶基]-2-甲基-4,6-喹啉二胺)
目录号 : KF1074
CAS No. : 733767-34-5
纯度 : 98%
NSC-23766 (733767-34-5) is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) Trio and Tiam1 (IC50 ca. 50 μM) with no effect on the closely related Cdc42 or RhoA. In cells, it blocks serum or PDGF-induced Rac-1 activation and lamellipodia formation. NSC-23766 suppressed the growth of wild-type NIH 3T3 cells but was inactive in cells expressing the constitutively active Rac1 mutant, L61Rac1. It is a useful tool to probe the involvement of Rac1 in cell signalling. Off target effect: antagonist at muscarinic acetylcholine receptors. Cell permeable.
Other Forms of Rapamycin:
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| 分子式 |
C24H35N7.3HCl
|
| 分子量 |
530.98
|
| CAS号 |
733767-34-5
|
| 中文名称 |
N6-[2-[[4-(二乙基氨基)-1-甲基丁基]氨基]-6-甲基-4-嘧啶基]-2-甲基-4,6-喹啉二胺
|
| 储存方式 |
| Powder |
-20°C |
3 years |
| |
4°C |
2 years |
| In solvent |
-80°C |
6 months |
| |
-20°C |
1 month |
|