NSC-23766 (Synonyms:N6-[2-[[4-(二乙基氨基)-1-甲基丁基]氨基]-6-甲基-4-嘧啶基]-2-甲基-4,6-喹啉二胺)
目录号 : KF1074 CAS No. : 733767-34-5 纯度 : 98%
NSC-23766 (733767-34-5) is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) Trio and Tiam1 (IC50 ca. 50 μM) with no effect on the closely related Cdc42 or RhoA. In cells, it blocks serum or PDGF-induced Rac-1 activation and lamellipodia formation. NSC-23766 suppressed the growth of wild-type NIH 3T3 cells but was inactive in cells expressing the constitutively active Rac1 mutant, L61Rac1. It is a useful tool to probe the involvement of Rac1 in cell signalling. Off target effect: antagonist at muscarinic acetylcholine receptors. Cell permeable.
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5mg
In-stock
25mg
In-stock

Other Forms of Rapamycin:

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分子式
C24H35N7.3HCl
分子量
530.98
CAS号
733767-34-5
中文名称
N6-[2-[[4-(二乙基氨基)-1-甲基丁基]氨基]-6-甲基-4-嘧啶基]-2-甲基-4,6-喹啉二胺
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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