Adenosine dialdehyde - CAS:34240-05-6

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Adenosine dialdehyde (Synonyms:腺苷二醛)

目录号 : KM2924 CAS No. : 34240-05-6 纯度 : 98%

Data Sheet 产品使用指南

Adenosine Dialdehyde 是嘌呤核苷的类似物，是 S-腺苷同型半胱氨酸水解酶 (SAHH) 的不可逆抑制剂 (K_i=3.3 nM)。Adenosine Dialdehyde 具有抗肿瘤活性，可用于肿瘤研究。

规格	价格	是否有货
25mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

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生物活性

Adenosine dialdehyde, a purine nucleoside analogue, is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (K_i=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo and can be used for the cancer research.

体外研究

Adenosine dialdehyde suppresses MNB cell replication in tissue culture with concentra tions of 1.5 μM with producing 50% inhibition.

体内研究

Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; infused over a 7-day period ( minipump infusion)) significantly increases the mean life span of tumor bearing mice from 20.9 days in diluent treated controls to 35.3 days in AD treated animals.
Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; two 7-day periods interspersed by a 7-day drug free interval( minipump infusion))increases mean life span 80% in diluent treated controls (controls, 21.3 days; AD treated 38.4 days) in mice.
Adenosine dialdehyde (subcutaneous injection; 2-3 mg/kg; infused over a 7-day period ( minipump infusion)) does not exhibit any hematopoietic toxicity in mice, and it can significantly suppress murine neuroblastoma tumor growth with little systemic toxicity.

Animal Model:	Adult male A/J mice, weighing 20 to 25 g with MNB cells
Dosage:	1.5-2.5 mg/kg
Administration:	Subcutaneous injection; 1.5-2.5 mg/kg; two 7-day periods interspersed by a 7-day drug free interval (minipump infusion)
Result:	Significantly suppressed murine neuroblastoma tumor growth. Prolongs the life span of tumor bearing mice. Did not suppress hematopoiesis when administered by steady state infusion.

分子式

C₁₀H₁₁N₅O₄

分子量

265.23

CAS号

34240-05-6

中文名称

腺苷二醛；腺嘌呤核苷二醛

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 10 mg/mL (37.70 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.7703 mL	18.8516 mL	37.7031 mL
5 mM	0.7541 mL	3.7703 mL	7.5406 mL
10 mM	0.3770 mL	1.8852 mL	3.7703 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.08 mg/mL (7.84 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (7.84 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: 2.08 mg/mL (7.84 mM); Suspended solution; Need ultrasonic

此方案可获得 2.08 mg/mL (7.84 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。